CONEXEU SCIENCES INC.

9,481,123 Shares of Common Stock

This prospectus supplement is being filed by Conexeu Sciences Inc. (the "Company") to update and supplement information contained in the Company's prospectus dated May 11, 2026 (the "Prospectus"), under the heading "Principal and Registered Securityholders". The table identifying executive officers, directors and other registered securityholders, has been revised to correct immaterial errors in the number of shares of common stock of the Company being registered for certain registered securityholders that were acquired pursuant to the Company's Regulation Crowdfunding offering on September 19, 2025, or October 9, 2025. The total number of shares of common stock being registered remains unchanged; only the allocation of shares among certain registered securityholders has been corrected, and consequential corrections to the footnotes accompanying the table have been made. The number of shares of common stock beneficially owned by certain registered securityholders has increased following the date of the Prospectus, and the table has been updated accordingly.

This prospectus supplement updates and supplements the information in the Prospectus and is not complete without, and may not be delivered or utilized except in combination with, the Prospectus, including any amendments or supplements thereto. This prospectus supplement should be read in conjunction with the Prospectus and if there is any inconsistency between the information in the Prospectus and this prospectus supplement, you should rely on the information in this prospectus supplement.

The purchase of the securities offered by the Prospectus involves a high degree of risk. You should invest in our shares of common stock only if you can afford to lose your entire investment. You should carefully read and consider the section of the Prospectus entitled "Risk Factors" beginning on page 19 before buying any shares of our common stock.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offence.

The date of this prospectus supplement is May 14, 2026.

PRINCIPAL AND REGISTERED SECURITYHOLDERS

Unless the context otherwise requires, as used in this prospectus, "Registered Securityholders" refers to the Registered Securityholders named in this prospectus, or certain transferees, assignees or other successors-in-interest that may receive our securities from the Registered Securityholders.

We have prepared this prospectus to allow the Registered Securityholders to sell or otherwise dispose of, from time to time, up to 9,481,123 shares of common stock, which are comprised of (i) 750,000 shares of common stock issued by the Company pursuant the Debt Settlement Agreement, which were subsequently transferred to another party, (ii) 3,750,000 shares of common stock issued by the Company pursuant to the Private Placement, (iii) 416,667 shares of common stock issued by the Company pursuant to the Business Advisory Agreement, (iv) 397,789 shares of common stock issued by the Company pursuant to the Reg CF offering; (v) 3,750,000 shares of common stock issuable upon exercise of the Private Placement Warrants issued pursuant to the Private Placement, and (vi) 416,667 shares of common stock issuable upon exercise of the Business Advisory Warrants issued pursuant to the Business Advisory Agreement. Except for the beneficial ownership of securities of the Company, neither the Registered Securityholders nor any persons who have control over the Registered Securityholders have had any material relationship with us within the past three years.

On September 15, 2024, we entered into the Debt Settlement Agreement with 0865546 B.C. Ltd. whereby we issued 750,000 shares of common stock (pre-reverse split - 3,000,000 shares) in exchange for the settlement of an outstanding liability in the amount of $22,500 owing to 0865546 B.C. Ltd. for services rendered to the Company. The 750,000 shares were subsequently transferred to San Spirito Trust on July 7, 2025.

On May 16, 2025, we entered into the Business Advisory Agreement with Urs Meier, whereby Mr. Meier provides strategic analysis and advice on the Company's business objectives in Europe, including organizational meetings and developing the Company's business strategy in Europe, in exchange for the issuance to Mr. Meier of 416,667 Units at a deemed price of $0.40 per Unit. Each Unit consisted of one share of our common stock and one Warrant with each Warrant entitling the holder thereof to purchase one additional Warrant Share at an exercise price of $0.40 per Warrant Share having an expiry date of three years from the date of issuance of the Warrants.

On September 19, 2025 and October 9, 2025, we issued an aggregate of 2,499,962 shares of our common stock pursuant to our Reg CF offering, of which we are registering for resale 397,789 shares of our common stock issued in such Reg CF offering.

The table below sets forth:

• information regarding beneficial ownership of our common stock as of May 14, 2026, by: 

o each of the directors and executive officers, individually;

o all directors and executive officers as a group; and

o each person known to us to own beneficially more than 5% of any class of our voting securities; and

• the number of shares of common stock held by and registered for resale by means of this prospectus for the Registered Securityholders.

The Registered Securityholders include certain stockholders with "restricted securities" (as defined in Rule 144 under the Securities Act) who, because they acquired their capital stock from an affiliate or from us within the prior 12 months, would be unable to sell their securities pursuant to Rule 144 until we have been subject to the reporting requirements of Section 13 or Section 15(d) the Exchange Act for a period of at least 90 days. The Registered Securityholders may, or may not, elect to sell their shares of common stock covered by this prospectus, as and to the extent they may determine. Such sales, if any, will be made through brokerage transactions on Nasdaq at prevailing trading prices. As such, we will have no input if and when any Registered Securityholder may, or may not, elect to sell their shares of common stock or the prices at which any such sales may occur. See "Plan of Distribution." The number of shares of common stock being registered does not represent the number of shares of common stock eligible for future sale in the public market following our listing on Nasdaq. See "Shares Eligible for Future Sale."

Information concerning the Registered Securityholders may change from time to time and any changed information will be set forth in supplements to this prospectus, if and when necessary. The Registered Securityholders may sell all, some, or none of the shares of common stock covered by this prospectus, and therefore, we cannot determine the number of such shares of common stock that will be sold by the Registered Securityholders, or the amount or percentage of shares of common stock that will be held by the Registered Securityholders upon consummation of any particular sale.

In addition, the Registered Securityholders listed in the table below may have sold, transferred, or otherwise disposed of, or may sell, transfer, or otherwise dispose of, at any time and from time to time, shares of common stock in transactions exempt from the registration requirements of the Securities Act, after the date on which they provided the information set forth in the table below. The Registered Securityholders have not, nor have they within the past three years had, any position, office, or other material relationship with us, other than as disclosed in this prospectus.

Notes:

* Less than one percent.

(1) Under Rule 13d-3 of the Exchange Act a beneficial owner of a security includes any person who, directly or indirectly, through any contract, arrangement, understanding, relationship or otherwise has or shares: (i) voting power, which includes the power to vote or to direct the voting of shares; and (ii) investment power, which includes the power to dispose or direct the disposition of shares. Certain shares may be deemed to be beneficially owned by more than one person (if, for example, persons share the power to vote or the power to dispose of the shares). In addition, shares are deemed to be beneficially owned by a person if the person has the right to acquire the shares (for example, upon exercise of an option) within 60 days of the date as of which the information is provided. In computing the percentage ownership of any person, the amount of shares outstanding is deemed to include the amount of shares beneficially owned by such person (and only such person) by reason of these acquisition rights. The applicable percentage of ownership is based on 25,269,996 shares of our common stock issued and outstanding as of May 14, 2026.

(2) This figure consists of (i) 87,861 shares of common stock held directly by Mr. Harrison, and (ii) 150,000 shares of common stock held of record by Mr. Harrison's spouse.

(3) This figure consists of (i) 500,000 shares of common stock held directly by Mr. Sharpe, and (ii) 500,000 performance warrants held by Mr. Sharpe to acquire 500,000 shares of common stock, which will vest within 60 days.

(4) This figure consists of (i) 87,861 shares of common stock held directly by Mr. Pilcher, and (ii) 100,000 stock options held by Critical Mass Scientific Strategy Consultants, LLC, over which Mr. Pilcher has sole voting and dispositive power, to acquire 100,000 shares of common stock, which have vested.

(5) This figure consists of (i) 444,111 shares of common stock held by Ms. Chavez-Munoz, and (ii) 50,000 stock options to acquire 50,000 shares of common stock, which will vest within 60 days.

(6) This figure consists of (i) 57,525 shares of common stock held by Mr. Inouye, and (ii) 75,000 stock options to acquire 75,000 shares of common stock which have vested.

(7) This figure consists of (i) 1,047,500 shares of common stock held by OnePointTwo Capital Ventures LLC, (ii) 1,484,240 shares of common stock held by OnePointTwo Capital Ventures II LLC, and (iii) 202,500 warrants held by OnePointTwo Capital Ventures LLC to acquire 202,500 shares of common stock. 422,500 warrants held by OnePointTwo Capital Ventures LLC to acquire 422,500 shares of common stock have been excluded as the holder together with any person or entity acting jointly or in concert are subject to a 9.99% beneficial ownership limitation. OnePointTwo Capital Performance LLC is the managing member of OnePointTwo Capital Ventures LLC and OnePointTwo Capital Ventures II LLC, and Sebastian Purcell has voting and dispositive power over these securities. Mr. Purcell disclaims beneficial ownership of the securities reported herein, except to the extent of his pecuniary interest therein.

(8) This figure consists of 10,869 shares of common stock held by Caloosa Consulting PLLC, over which Mr. Farberg has sole voting and dispositive power.

(9) This figure consists of (i) 1,062,500 shares of common stock held directly by Mr. Bogart, (ii) 431,250 shares of common stock held by 0865546 B.C. Ltd., over which Mr. Bogart has sole voting and dispositive power, (iii) 50,000 stock options to acquire 50,000 shares of common stock, which have vested, and (iv) 500,000 performance warrants held by Mr. Bogart to acquire 500,000 shares of common stock, which have vested or will vest within 60 days.

(10) This figure consists of 433,323 shares of common stock held directly by Dr. Lorenc.

(11) This figure consists of (i) 5,797,040 shares of common stock, (ii) 275,000 stock options to acquire 275,000 shares of common stock, which have vested, (iii) 202,500 warrants to acquire 202,500 shares of common stock, which have vested, and (iv) 1,000,000 performance warrants to acquire 1,000,000 shares of common stock, which have vested or will vest within 60 days.

(12) This figure consists of (i) 750,000 shares of common stock held directly by Mr. Wright, (ii) 1,353,048 shares of common stock held by N3GU Investments LLC, over which Mr. Wright has sole voting and dispositive power, (iii) 50,000 stock options to acquire 50,000 shares of common stock, which have vested, (iv) 78,595 warrants to acquire 78,595 shares of common stock held by N3GU Investments LLC, and (v) 400,000 performance warrants held by N3GU Investments LLC to acquire 400,000 shares of common stock, which have vested or will vest within 60 days.

(13) This figure consists of (i) 1,047,500 shares of common stock held by OnePointTwo Capital Ventures LLC, (ii) 1,484,240 shares of common stock held by OnePointTwo Capital Ventures II LLC, and (iii) 202,500 warrants held by OnePointTwo Capital Ventures LLC to acquire 202,500 shares of common stock. 422,500 warrants held by OnePointTwo Capital Ventures LLC to acquire 422,500 shares of common stock have been excluded as the holder together with any person or entity acting jointly or in concert are subject to a 9.99% beneficial ownership limitation. OnePointTwo Capital Performance LLC is the managing member of OnePointTwo Capital Ventures LLC and OnePointTwo Capital Ventures II LLC, and Sebastian Purcell has voting and dispositive power over these securities.

(14) This figure consists of 1,800,000 shares of common stock held by Paisley Capital Holdings Corporation. Each of Franz Buser and Jacqueline Elsener have voting and dispositive power over these shares.

(15) This figure consists of (i) 2,200,000 shares of common stock held by Quintus Growth Fund, and (ii) 360,000 warrants to acquire 360,000 shares of our common stock. 1,840,000 warrants held by Quintus Growth Fund to acquire 1,840,000 shares of common stock have been excluded as the holder together with any person or entity acting jointly or in concert are subject to a 9.99% beneficial ownership limitation. Each of Sven Soro and Wilhelm Zehender have voting and dispositive power over these securities.

(16) This figure includes: (i) 1,000,000 shares of our common stock held by Ms. Suffron; and (ii) 300,000 warrants to purchase 300,000 shares of our common stock exercisable within 60 days.

(17) This figure includes: (i) 625,000 shares of our common stock held by Mr. Tait; and (ii) 312,500 warrants to purchase 312,500 shares of our common stock exercisable within 60 days.

(18) This figure includes: (i) 625,000 shares of our common stock held by Mr. Pamer; and (ii) 312,500 warrants to purchase 312,500 shares of our common stock exercisable within 60 days.

(19) This figure includes: (i) 625,000 shares of our common stock held by Geppetto Holdings Ltd.; and (ii) 312,500 warrants to purchase 312,500 shares of our common stock exercisable within 60 days. Philip Tapley has voting and dispositive power over these shares.

(20) This figure includes: (i) 625,000 shares of our common stock held by Mr. Christensen; and (ii) 312,500 warrants to purchase 312,500 shares of our common stock exercisable within 60 days.

(21) This figure includes: (i) 416,667 shares of our common stock held by Mr. Meier; and (ii) 416,667 warrants to purchase 416,667 shares of our common stock exercisable within 60 days.

(22) This figure includes 750,000 shares of our common stock only.  Diana Claxton-Whittaker has voting and dispositive power over these shares.

(23) Kerry Anne Merkt has voting and dispositive power over these shares.

(24) Allen Collins has voting and dispositive power over these shares.

(25) Ansel Drummond has voting and dispositive power over these shares.

(26) Carolyn Luu has voting and dispositive power over these shares.

(27) Daniel Denham has voting and dispositive power over these shares.

(28) Denise Squires has voting and dispositive power over these shares.

(29) Edith Falls has voting and dispositive power over these shares.

(30) Garo Artinian has voting and dispositive power over these shares.

(31) Hayward Babin has voting and dispositive power over these shares.

(32) Jay Reichert has voting and dispositive power over these shares.

(33) Jeannette Berman has voting and dispositive power over these shares.

(34) John Hwung has voting and dispositive power over these shares.

(35) John Peoples has voting and dispositive power over these shares.

(36) Joseph Brady Amoon has voting and dispositive power over these shares.

(37) Karen Zicht has voting and dispositive power over these shares.

(38) Lewis Kemmerer, Jr has voting and dispositive power over these shares.

(39) Lloyd Thomason has voting and dispositive power over these shares.

(40) Martha Thomas has voting and dispositive power over these shares.

(41) Michael Hlavin has voting and dispositive power over these shares.

(42) Michael Hu has voting and dispositive power over these shares.

(43) Michael Lee has voting and dispositive power over these shares.

(44) Moni Mosharaf has voting and dispositive power over these shares.

(45) Ralph Kato has voting and dispositive power over these shares.

(46) Richard Nelson has voting and dispositive power over these shares.

(47) Robert Abel has voting and dispositive power over these shares.

(48) Sawako Suzuki has voting and dispositive power over these shares.

(49) Shane Carr has voting and dispositive power over these shares.

(50) Steven Marks has voting and dispositive power over these shares.

(51) Thomas Happensack has voting and dispositive power over these shares.

(52) Krishnan Rambadhran has voting and dispositive power over these shares.

(53) Michael Wiltsey has voting and dispositive power over these shares.

(54) Scott Yancy has voting and dispositive power over these shares.

(55) Boris Aronovhas voting and dispositive power over these shares.

(56) Terri Labberton has voting and dispositive power over these shares.

(57) Don Blackhurst has voting and dispositive power over these shares.

(58) Adwynna Mackenzi has voting and dispositive power over these shares.

(59) Richard Bloomfield has voting and dispositive power over these shares.

(60) Graham Mitchell has voting and dispositive power over these shares.

(61) Christine Nawrocki has voting and dispositive power over these shares.

(62) Dave LaRose has voting and dispositive power over these shares.

(63) Owen Hammond has voting and dispositive power over these shares.

(64) Kathryn Cole has voting and dispositive power over these shares.

(65) Coral Kline has voting and dispositive power over these shares.

(66) James Burian has voting and dispositive power over these shares.

(67) Jon Danski has voting and dispositive power over these shares.

(68) David Jolivet has voting and dispositive power over these shares.

(69) Donald Peven has voting and dispositive power over these shares.

(70) Andrew Rountree has voting and dispositive power over these shares.

(71) Stephen Lewis has voting and dispositive power over these shares.

(72) Owen Hammond has voting and dispositive power over these shares.

(73) Guillaume Plourde has voting and dispositive power over these shares.

(74) William Miller has voting and dispositive power over these shares.

(75) Barry Cote has voting and dispositive power over these shares.

(76) Guy Brown has voting and dispositive power over these shares.

(77) Keith Hennek has voting and dispositive power over these shares.

(78) Jo Anne Herman has voting and dispositive power over these shares.

(79) Ijaz Khan has voting and dispositive power over these shares.

(80) James Olson has voting and dispositive power over these shares.

(81) James Cook has voting and dispositive power over these shares.

(82) James Kelly has voting and dispositive power over these shares.

(83) Kevin Ruark has voting and dispositive power over these shares.

(84) John Schmitz has voting and dispositive power over these shares.

(85) Kirk Hirano has voting and dispositive power over these shares.

(86) Lealand Dean has voting and dispositive power over these shares.

(87) Kenneth Morrow has voting and dispositive power over these shares.

(88) Laurence Wildes has voting and dispositive power over these shares.

(89) Albert Lee has voting and dispositive power over these shares.

(90) Philip Lurie has voting and dispositive power over these shares.

(91) Lynda Sapsai has voting and dispositive power over these shares.

(92) David Bolling has voting and dispositive power over these shares.

(93) Robert Koppelman has voting and dispositive power over these shares.

(94) Craig Mattner has voting and dispositive power over these shares.

(95) Mike Mathioudakis has voting and dispositive power over these shares.

(96) Vesa Koskinen has voting and dispositive power over these shares.

(97) Eugene Hoang has voting and dispositive power over these shares.

(98) Naylor Trust has voting and dispositive power over these shares.

(99) David Meade has voting and dispositive power over these shares.

(100) Neal Clements has voting and dispositive power over these shares.

(101) Ross O'Reilly has voting and dispositive power over these shares.

(102) Patrick Sklodowski has voting and dispositive power over these shares.

(103) Andrew Keethler has voting and dispositive power over these shares.

(104) Paul Bull has voting and dispositive power over these shares.

(105) Michael Kinne has voting and dispositive power over these shares.

(106) Cynthia McEwans Haynes has voting and dispositive power over these shares.

(107) Jeffrey Ramsey has voting and dispositive power over these shares.

(108) Richard Michaud has voting and dispositive power over these shares.

(109) Richard Sojka has voting and dispositive power over these shares.

(110) Maximiliano Rinaldi has voting and dispositive power over these shares.

(111) Darrel Sandall has voting and dispositive power over these shares.

(112) Scott Maddox has voting and dispositive power over these shares.

(113) Hoa Tran has voting and dispositive power over these shares.

(114) Vincent Sier has voting and dispositive power over these shares.

(115) Scott Haugh has voting and dispositive power over these shares.

(116) Stanley Greenberg has voting and dispositive power over these shares.

(117) Sylvan Stoltzfoos has voting and dispositive power over these shares.

(118) Mark Burnworth has voting and dispositive power over these shares.

(119) Judith Hazelett has voting and dispositive power over these shares.

(120) Merl Kinser has voting and dispositive power over these shares.

(121) Dale Roy has voting and dispositive power over these shares.

(122) Mario santos has voting and dispositive power over these shares.

(123) John Whitley has voting and dispositive power over these shares.

(124) John Newhouser has voting and dispositive power over these shares.

(125) Jeffrey Li has voting and dispositive power over these shares.

(126) Andrew Rountree has voting and dispositive power over these shares.

(127) Walter Obrien has voting and dispositive power over these shares.

(128) William Hoefle has voting and dispositive power over these shares.